It houses mainly works owned by the diocese or from decommissioned churches. Located in the rooms of the former Pontifical Regional Seminary, it is divided into its sections: Lapidary and Museum Collection. The first houses a sampler of epigraphic, ornamental and figurative artifacts and a collection of coats of arms of Fano bishops.
The Museum Collection, on the other hand, offers works of historical, artistic and liturgical interest such as reliquaries, wood-carved and painted crucifixes, canvases of the Venetian school, wooden statues and vestments, as well as an ivory crosier, a gift from Pius V.